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Abstract 12654: Direct Oral Anticoagulants (DOAC) versus Warfarin for the Treatment of Left Ventricular Thrombus (LVT) in Patients With or Without Cardiorenal Comorbidities, Including CKD (Chronic Kidney Disease) and Atrial Fibrillation: A Systematic Review and Meta-Analysis | Circulation.A meta-analysis of these 3 randomized controlled trials, which consisted of a total of 139 patients, found DOACs to be noninferior to VKA with respect to mortality, stroke, or LV thrombus resolution. 93 Pooled analysis also showed that major bleeding was significantly lower with DOACs (2.86% with DOACs versus 13.2% with warfarin; OR, .
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The American and European guidelines recommend oral anticoagulant therapy with warfarin with varying durations from 3-6 months. However, there are no prospective trials comparing warfarin and direct oral anticoagulants(DOACs) as anticoagulation in the treatment of LV thrombus.
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